Endocrine Abstracts

Background: Visceral obesity has been associated with systemic oxidative stress, measured by oxidized LDL (oxLDL).Aim: Investigate circulating oxLDL levels in patients with visceral obesity, and its relationship with metabolic abnormalities found in visceral obesity.Methods: We evaluated blood pressure (BP), waist circumference (WC), fasting glucose, total cholesterol, LDL, HDL, triglycerides, ApoA1, ApoB, ApoCIII, Lp(a) and oxLDL ...

Introduction: Primary hyperparathyroidism (PHPT) patients who undergo parathyroidectomy can develop isolated intact parathormone (iPTH) elevation with normal calcemia. Common causes are: renal insufficiency (RI), vitamin D deficit and hypomagnesemia.Aim: To identify clinical factors associated with iPTH elevation in patients submitted to surgery treatment.Methods: The medical records of patients admitted into Santo António&#14...

Introduction: Acromegaly is a rare disease caused by an increased secretion of GH, usually derived from a benign pituitary tumor. Women with acromegaly are usually infertile, because of tumoral hypersecretion, compression or surgical sequelae. We can prevent infertility with an adequate treatment. There are some reports describing pregnacies among acromegalic women. It is believed that there is an increased risk of develloping diabetes mellitus and hypertension, especially whe...

Introduction: Pituitary apoplexy is a potentially life-threatening syndrome due to acute infarction and/or hemorrhage of the pituitary gland. In many cases it is the first form of presentation of a pituitary adenoma. The purpose of the study is to analyze the clinical presentation, diagnosis and treatment of this syndrome.Patients and methods: A retrospective analysis of the patients diagnosed with pituitary tumor apoplexy at Santo Antonio’s Hospita...

Aims/hypothesis: Several data have shown the association between diabetes type 2 (DM2) and transcription factor 7-like 2 (TCF7L2) gene polymorphisms, in several and different ethnical populations. Although the pathophysiology is not completely clear, it seems that beta and alpha cell functions are abnormal. Up to these days there is no clinical data showing association between TCF7L2 gene polymorphism allele rs7903146 T and beta cell insulin and C-peptide contents in DM2 patie...